2026-06-14T00:32:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/83792024-09-27T10:10:42Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Mlecnik, Bernhard
author
Sanchez-Cabo, Fatima
author
Charoentong, Pornpimol
author
Bindea, Gabriela
author
Pagès, Franck
author
Berger, Anne
author
Galon, Jerome
author
Trajanoski, Zlatko
funder
Australian Ministry for Science and Research
funder
Australian Science Fund
funder
Fondation ARC pour la recherche sur le cancer
funder
Unión Europea. Comisión Europea
2019-09-25T08:01:36Z
2019-09-25T08:01:36Z
2010-02
BMC Genomics. 2010; 11 Suppl 1:S7
10.1186/1471-2164-11-S1-S7
1471-2164
1471-2164
BMC genomics
20158878
http://hdl.handle.net/20.500.12105/8379
Cancer progression is a complex process involving host-tumor interactions by multiple molecular and cellular factors of the tumor microenvironment. Tumor cells that challenge immune activity may be vulnerable to immune destruction. To address this question we have directed major efforts towards data integration and developed and installed a database for cancer immunology with more than 1700 patients and associated clinical data and biomolecular data. Mining of the database revealed novel insights into the molecular mechanisms of tumor-immune cell interaction. In this paper we present the computational tools used to analyze integrated clinical and biomolecular data. Specifically, we describe a database for heterogeneous data types, the interfacing bioinformatics and statistical tools including clustering methods, survival analysis, as well as visualization methods. Additionally, we discuss generic issues relevant to the integration of clinical and biomolecular data, as well as recent developments in integrative data analyses including biomolecular network reconstruction and mathematical modeling.
eng
Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction
journal article
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URL
https://repisalud.isciii.es/bitstreams/c7ccabda-ab00-4d4a-a790-7d158962ecf0/download
File
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application/pdf
DataIntegrationExplorationIdentification_2010.pdf
URL
https://repisalud.isciii.es/bitstreams/c91e5e0c-d937-496b-b122-2da1d6e9cbd2/download
File
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text/plain
DataIntegrationExplorationIdentification_2010.pdf.txt