2026-04-29T04:08:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/83642024-11-29T20:23:43Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Brandariz, Lorena
author
Arriba, María
author
García, Juan Luis
author
Cano, Juana María
author
Rueda, Daniel
author
Rubio, Eduardo
author
Rodríguez, Yolanda
author
Pérez, Jessica
author
Vivas, Alfredo
author
Sánchez, Carmen
author
Tapial, Sandra
author
Pena, Laura
author
García-Arranz, Mariano
author
García-Olmo, Damián
author
Urioste, Miguel
author
González-Sarmiento, Rogelio
author
Perea, José
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-09-23T09:38:49Z
2019-09-23T09:38:49Z
2018-03-16
Oncotarget. 2018 ;9(20):15302-15311.
1949-2553
http://hdl.handle.net/20.500.12105/8364
29632645
10.18632/oncotarget.24502
1949-2553
Oncotarget
Background: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). Results: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers. Materials and Methods: We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon. Conclusions: Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC.
eng
CpG island methylator phenotype
chromosomal instability
colon location
late-onset colorectal cancer
microsatellite instability
Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location
journal article
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