2026-04-29T04:08:50Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/83642024-11-29T20:23:43Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Brandariz, Lorena author Arriba, María author García, Juan Luis author Cano, Juana María author Rueda, Daniel author Rubio, Eduardo author Rodríguez, Yolanda author Pérez, Jessica author Vivas, Alfredo author Sánchez, Carmen author Tapial, Sandra author Pena, Laura author García-Arranz, Mariano author García-Olmo, Damián author Urioste, Miguel author González-Sarmiento, Rogelio author Perea, José author 2018-03-16 Background: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). Results: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers. Materials and Methods: We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon. Conclusions: Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC. Oncotarget. 2018 ;9(20):15302-15311. 1949-2553 http://hdl.handle.net/20.500.12105/8364 29632645 10.18632/oncotarget.24502 1949-2553 Oncotarget CpG island methylator phenotype chromosomal instability colon location late-onset colorectal cancer microsatellite instability Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location