2026-06-14T02:29:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/83632024-11-29T13:33:31Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Quintanal-Villalonga, Alvaro
author
Mediano, Mariló
author
Ferrer, Irene
author
Meléndez, Ricardo
author
Carranza-Carranza, Andrés
author
Suárez, Rocío
author
Carnero, Amancio
author
Molina-Pinelo, Sonia
author
Paz Ares, Luis Gonzaga
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación Mutua Madrileña
funder
European Regional Development Fund
funder
Asociación Española Contra el Cáncer
2019-09-23T09:14:09Z
2019-09-23T09:14:09Z
2018-04-13
Oncotarget. 2018 ;9(28):19945-19960
10.18632/oncotarget.24977
1949-2553
1949-2553
Oncotarget
29731995
http://hdl.handle.net/20.500.12105/8363
Lung tumors represent a major health problem. In early stage NSCLC tumors, surgical resection is the preferred treatment, but 30-55% of patients will relapse within 5 years after surgery. Thus, the identification of prognostic biomarkers in early stage NSCLC patients, especially those which are therapeutically addressable, is crucial to enhance survival of these patients. We determined the immunohistochemistry expression of key proteins involved in tumorigenesis and oncogenic signaling, p53, EGFR, pAKT and pERK, and correlated their expression level to clinicopathological characteristics and patient outcome. We found EGFR expression is higher in the squamous cell carcinomas than in adenocarcinomas (p=0.043), and that nuclear p53 staining correlated with lower differentiated squamous tumors (p=0.034). Regarding the prognostic potential of the expression of these proteins, high pERK levels proved to be an independent prognostic factor for overall (p<0.001) and progression-free survival (p<0.001) in adenocarcinoma patients, but not in those from the squamous histology, and high p53 nuclear levels were identified as independent prognostic factor for progression-free survival (p=0.031) only in squamous cell carcinoma patients. We propose a role as early prognostic biomarkers for pERK protein levels in adenocarcinoma, and for nuclear p53 levels in squamous cell lung carcinoma. The determination of these potential biomarkers in the adequate histologic context may predict the outcome of early stage NSCLC patients, and may offer a therapeutic opportunity to enhance survival of these patients.
eng
NSCLC
biomarkers
p53
pERK
prognostic
Histology-dependent prognostic role of pERK and p53 protein levels in early-stage non-small cell lung cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/f2663f9d-a4d7-48a7-92a6-62e1e35ececd/download
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Histology-dependentprognosticrole_2018.pdf
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https://repisalud.isciii.es/bitstreams/5f0b735e-ee15-4a0a-b3bc-10554ad0f845/download
File
MD5
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text/plain
Histology-dependentprognosticrole_2018.pdf.txt