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oai:repisalud.isciii.es:20.500.12105/83572024-11-29T18:04:07Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Freitas-Simoes, Tania-Marisa author Cofán, Montserrat author Blasco , MA author Soberón, Nora author Foronda, Miguel author Serra-Mir, Mercè author Roth, Irene author Valls-Pedret, Cinta author Doménech, Mónica author Ponferrada-Ariza, Elena author Calvo, Carlos author Rajaram, Sujatha author Sabaté, Joan author Ros, Emilio author Sala-Vila, Aleix author 2018-12-04 Randomized controlled trials on diet and shortening of leukocyte telomere length (LTL) mostly focus on marine-derived n-3 polyunsaturated fatty acids (PUFA). Walnuts are a sustainable source of n-3 PUFA. We investigated whether inclusion of walnuts (15% of energy) in the diet for 2 years would maintain LTL in cognitively healthy elders (63⁻79 years old) compared to a control group (habitual diet, abstaining from walnuts). This opportunistic sub-study was conducted within the Walnuts and Healthy Aging study, a dual-centre (Barcelona, Spain and Loma Linda University, California) parallel trial. A sub-set of the Barcelona site participants were randomly assigned to the walnut (n = 80) or control group (n = 69). We assessed LTL at baseline and at 2 years and we conducted repeated-measures ANCOVA with 2 factors: time (baseline, 2 years) and group (control, walnut) and their interaction. Adjusted means (95% confidence interval) of LTL (in kb) in controls were 7.360 (7.084,7.636) at baseline and 7.061 (6.835,7.288) after 2 years; corresponding values in the walnut group were 7.064 (6.807,7.320) and 7.074 (6.864,7.284). The time × intervention interaction was nearly significant (p = 0.079), suggestive of a trend of walnut consumption in preserving LTL. This exploratory research finding should be confirmed in trials with adequate statistical power. J Acad Nutr Diet. ;118(12):2254-2268. 10.3390/nu10121907 2072-6643 2072-6643 Nutrients 30518050 http://hdl.handle.net/20.500.12105/8357 aging alpha-linolenic acid biomarker n-3 PUFA nuts Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial