2026-07-22T03:36:37Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/83562024-11-30T00:46:00Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud author Horne, Hisani N author Oh, Hannah author Sherman, Mark E author Palakal, Maya author Hewitt, Stephen M author Schmidt, Marjanka K author Milne, Roger L author Hardisson, David author Benitez, Javier author Blomqvist, Carl author Bolla, Manjeet K author Brenner, Hermann author Chang-Claude, Jenny author Cora, Renata author Couch, Fergus J author Cuk, Katarina author Devilee, Peter author Easton, Douglas F author Eccles, Diana M author Eilber, Ursula author Hartikainen, Jaana M author Heikkilä, Päivi author Holleczek, Bernd author Hooning, Maartje J author Jones, Michael author Keeman, Renske author Mannermaa, Arto author Martens, John W M author Muranen, Taru A author Nevanlinna, Heli author Olson, Janet E author Orr, Nick author Perez, Jose I A author Pharoah, Paul D P author Ruddy, Kathryn J author Saum, Kai-Uwe author Schoemaker, Minouk J author Seynaeve, Caroline author Sironen, Reijo author Smit, Vincent T H B M author Swerdlow, Anthony J author Tengström, Maria author Thomas, Abigail S author Timmermans, A Mieke author Tollenaar, Rob A E M author Troester, Melissa A author van Asperen, Christi J author van Deurzen, Carolien H M author Van Leeuwen, Flora F author Van't Veer, Laura J author García-Closas, Montserrat author Figueroa, Jonine D funder National Breast Cancer Foundation (Australia) funder Cancer Australia funder National Institutes of Health (Estados Unidos) funder Cancer Research UK (Reino Unido) funder Unión Europea. Comisión Europea. European Research Council (ERC) funder Dutch Cancer Society (Holanda) funder Instituto de Salud Carlos III funder Asociación Española Contra el Cáncer funder Ministry of Science, Research and the Arts of Baden-Wuerttemberg (Alemania) funder German Cancer Aid funder Finlands Akademi (Finlandia) funder Cancer Society of Finland funder Nordic Cancer Union (Islandia) funder Sigrid Jusélius Foundation funder Cancer Society of North Savo funder Finnish Cancer Organizations funder University of Eastern Finland (Finlandia) funder Cancer Council Queensland (Australia) funder Cancer Council New South Wales (Australia) funder Cancer Council Victoria (Australia) funder Cancer Council Tasmania (Australia) funder Cancer Council of South Australia (Australia) funder Cancer Council Western Australia (Australia) funder United States Army Medical Research and Development Command funder National Health and Medical Research Council (Australia) funder NIH - National Cancer Institute (NCI) (Estados Unidos) funder Institute of Cancer Research (Reino Unido) 2019-09-18T08:46:30Z 2019-09-18T08:46:30Z 2018-04-26 Sci Rep. 2018 ;8(1):6574. 10.1038/s41598-018-23733-4 2045-2322 2045-2322 Scientific reports 29700408 http://hdl.handle.net/20.500.12105/8356 E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes. eng E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium journal article TElDRU5DSUEgREUgRElTVFJJQlVDScOTTiBOTyBFWENMVVNJVkEKCkFjZXB0YW5kbyBlc3RhIGxpY2VuY2lhLCBVc3RlZCAoZWwgYXV0b3IvZXMgbyBlbCBwcm9waWV0YXJpby9zIGRlIGxvcyBkZXJlY2hvcyBkZSAKYXV0b3IpIGNvbmNlZGUgYSBSRVBJU0FMVUQgZWwgZGVyZWNobyBubyBleGNsdXNpdm8gZGUgcmVwcm9kdWNpciwgY29udmVydGlyLCB5L28gCmRpc3RyaWJ1aXIgc3UgZG9jdW1lbnRvIChpbmNsdXllbmRvIHN1IHJlc3VtZW4pIGEgbml2ZWwgbXVuZGlhbCBlbiBmb3JtYXRvIGRpZ2l0YWwsIAppbmNsdXllbmRvLCBhdWRpbyB5IHbDrWRlbywgYSB0cmF2w6lzIGRlIHN1IHJlcG9zaXRvcmlvIGluc3RpdHVjaW9uYWwuCgpVc3RlZCBhY2VwdGEgcXVlIFJFUElTQUxVRCBwdWVkZSwgc2luIGFsdGVyYXIgc3UgY29udGVuaWRvLCBjb252ZXJ0aXIgc3UgZG9jdW1lbnRvIAphIGN1YWxxdWllciBvdHJvIGZvcm1hdG8gZGlnaXRhbCBkZSBkYXRvcywgYXVkaW8geSB2aWRlbywgY29uIGVsIHByb3DDs3NpdG8gZGUgcXVlIApwdWVkYSBzZXIgYWxvamFkbyBlbiBlbCByZXBvc2l0b3Jpby4gCgpVc3RlZCBlc3TDoSBkZSBhY3VlcmRvIGNvbiBxdWUgUkVQSVNBTFVEIHB1ZWRhIGNvbnNlcnZhciBtw6FzIGRlIHVuYSBjb3BpYSBkZSBlc3RlIApkb2N1bWVudG8gcGFyYSBhc2VndXJhciBzdSBzZWd1cmlkYWQsIHByZXNlcnZhY2nDs24geSBhY2Nlc28uCgpVc3RlZCBkZWNsYXJhIHF1ZSBlbCBkb2N1bWVudG8gZXMgdW4gdHJhYmFqbyBvcmlnaW5hbCwgeSBxdWUgdGllbmUgZWwgZGVyZWNobyBkZSAKb3RvcmdhciBsb3MgZGVyZWNob3MgY29udGVuaWRvcyBlbiBlc3RhIGxpY2VuY2lhLiBUYW1iacOpbiBkZWNsYXJhIHF1ZSBzdSBwZXRpY2nDs24gCm5vIGluZnJpbmdlIGxvcyBkZXJlY2hvcyBkZSBhdXRvciBkZSBuYWRpZS4gCgpTaSBlbCBkb2N1bWVudG8gY29udGllbmUgbWF0ZXJpYWxlcyBwYXJhIGxvcyBxdWUgbm8gc2UgdGllbmVuIGxvcyBkZXJlY2hvcyBkZSBhdXRvciwgClVzdGVkIGRlY2xhcmEgcXVlIGhhIG9idGVuaWRvIGVsIHBlcm1pc28gc2luIHJlc3RyaWNjacOzbiBkZWwgcHJvcGlldGFyaW8gZGUgbG9zIApkZXJlY2hvcyB5IHF1ZSBlbiBkaWNobyBtYXRlcmlhbCwgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZGEgeSByZWNvbm9jaWRhIHN1IAphdXRvcsOtYSBkZW50cm8gZWwgdGV4dG8gbyBkZWwgY29udGVuaWRvIGRlIGRpY2hvIGRvY3VtZW50by4gCgpTaSBlbCBlbnbDrW8gc2UgYmFzYSBlbiB1biB0cmFiYWpvIHF1ZSBoYSBzaWRvIHBhdHJvY2luYWRvIG8gYXBveWFkbyBwb3IgdW5hIGFnZW5jaWEgCnUgb3JnYW5pemFjacOzbiBkaXN0aW50YSBhIFJFUElTQUxVRCwgdXN0ZWQgYWNlcHRhIHF1ZSBoYSBjdW1wbGlkbyBjb24gZWwgZGVyZWNobyBkZSAKcmV2aXNpw7NuIHkgb3RyYXMgb2JsaWdhY2lvbmVzIHJlcXVlcmlkYXMgcG9yIGNvbnRyYXRvIG8gYWN1ZXJkby4gCgpSRVBJU0FMVUQgaWRlbnRpZmljYXLDoSBjbGFyYW1lbnRlIHN1KHMpIG5vbWJyZShzKSBjb21vIGF1dG9yKHMpIG8gcHJvcGlldGFyaW8ocykgCmRlbCBkb2N1bWVudG8sIHkgbm8gaGFyw6EgbmluZ3VuYSBhbHRlcmFjacOzbiwgZXhjZXB0byBzZWfDum4gbG8gcGVybWl0aWRvIHBvciBlc3RhIApsaWNlbmNpYS4gCg== URL https://repisalud.isciii.es/bitstreams/9c4e807c-9939-4c7a-b2d4-fd3fac845cdf/download File MD5 3f546b67975d72cda19aa6e1a669a13e 891722 application/pdf E-cadherinbreasttumor _2018.pdf URL https://repisalud.isciii.es/bitstreams/bbc95e67-1b3a-42db-ba8e-b09fcab3c361/download File MD5 68b31d6d0f794ad13382858982007700 64416 text/plain E-cadherinbreasttumor _2018.pdf.txt