2026-04-29T22:57:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/83212024-09-27T09:09:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Sanz-Morejon, Andres author Garcia-Redondo, Ana B author Reuter, Hanna author Marques, Ines Joao author Bates, Thomas author Galardi-Castilla, Maria author Große, Andreas author Manig, Steffi author Langa, Xavier author Ernst, Alexander author Piragyte, Indre author Botos, Marius-Alexandru author Gonzalez-Rosa, Juan Manuel author Ruiz-Ortega, Marta author Briones, Ana M author Salaices, Mercedes author Englert, Christoph author Mercader, Nadia author 2019-07 Organ regeneration is preceded by the recruitment of innate immune cells, which play an active role during repair and regrowth. Here, we studied macrophage subtypes during organ regeneration in the zebrafish, an animal model with a high regenerative capacity. We identified a macrophage subpopulation expressing Wilms tumor 1b (wt1b), which accumulates within regenerating tissues. This wt1b+ macrophage population exhibited an overall pro-regenerative gene expression profile and different migratory behavior compared to the remainder of the macrophages. Functional studies showed that wt1b regulates macrophage migration and retention at the injury area. Furthermore, wt1b-null mutant zebrafish presented signs of impaired macrophage differentiation, delayed fin growth upon caudal fin amputation, and reduced cardiomyocyte proliferation following cardiac injury that correlated with altered macrophage recruitment to the regenerating areas. We describe a pro-regenerative macrophage subtype in the zebrafish and a role for wt1b in organ regeneration. Cell Rep. 2019; 28(5):1296-1306 10.1016/j.celrep.2019.06.091 2211-1247 22111247 Cell reports 31365871 http://hdl.handle.net/20.500.12105/8321 Wilms tumor 1b Fin regeneration Heart regeneration Macrophages Zebrafish Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish