2026-06-14T10:38:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/83122024-11-29T13:52:49Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Simón-Carrasco, Lucía
author
Jiménez, Gerardo
author
Barbacid, Mariano
author
Drosten, Matthias
funder
Fundación La Marató TV3
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Comunidad de Madrid (España)
funder
Asociación Española Contra el Cáncer
funder
Fundación AXA
funder
Ministerio de Economía y Competitividad (España)
2019-08-22T08:20:46Z
2019-08-22T08:20:46Z
2018-06-17
Cell Cycle. 2018;17(6):702-711.
10.1080/15384101.2018.1450029
1551-4005
1538-4101
Cell cycle (Georgetown, Tex.)
29578365
http://hdl.handle.net/20.500.12105/8312
The transcriptional repressor Capicua (CIC) has emerged as an important rheostat of cell growth regulated by RAS/MAPK signaling. Cic was originally discovered in Drosophila, where it was shown to be inactivated by MAPK signaling downstream of the RTKs Torso and EGFR, which results in signal-dependent responses that are required for normal cell fate specification, proliferation and survival of developing and adult tissues. CIC is highly conserved in mammals, where it is also negatively regulated by MAPK signaling. Here, we review the roles of CIC during mammalian development, tissue homeostasis, tumor formation and therapy resistance. Available data indicate that CIC is involved in multiple biological processes, including lung development, liver homeostasis, autoimmunity and neurobehavioral processes. Moreover, CIC has been shown to be involved in tumor development as a tumor suppressor, both in human as well as in mouse models. Finally, several lines of evidence implicate CIC as a determinant of sensitivity to EGFR and MAPK pathway inhibitors, suggesting that CIC may play a broader role in human cancer than originally anticipated.
eng
CIC
Etv4
Ras signaling
T-ALL
mouse models
The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer
journal article
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TheCapicuatumorsuppressor_2018.pdf
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TheCapicuatumorsuppressoragatekeeper_figures_2018.pdf
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TheCapicuatumorsuppressor_2018.pdf.txt
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