2026-07-21T14:20:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/83102024-11-29T15:31:57Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Blasco, María Teresa
author
Navas, Carolina
author
Martín-Serrano, Guillermo
author
Graña Castro, Osvaldo
author
Lechuga, Carmen G
author
Martín-Díaz, Laura
author
Djurec, Magdolna
author
Li, Jing
author
Morales-Cacho, Lucia
author
Esteban-Burgos, Laura
author
Perales-Patón, Javier
author
Bousquet-Mur, Emilie
author
Castellano, Eva
author
Jacob, Harrys K C
author
Cabras, Lavinia
author
Musteanu, Mónica
author
Drosten, Matthias
author
Ortega, Sagrario
author
Mulero, Francisca
author
Sainz, Bruno
author
Dusetti, Nelson
author
Iovanna, Juan
author
Sanchez-Bueno, Francisco
author
Hidalgo, Manuel
author
Khiabanian, Hossein
author
Rabadan, Raul
author
Al-Shahrour, Fatima
author
Guerra, Carmen
author
Barbacid, Mariano
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Ministerio de Economía y Competitividad (España)
funder
Asociación Española Contra el Cáncer
funder
Ligue Nationale Contre le Cancer (Francia)
funder
NIH - National Cancer Institute (NCI) (Estados Unidos)
funder
Fundación La Caixa
funder
Fundación AXA
2019-08-21T09:13:18Z
2019-08-21T09:13:18Z
2019-04-15
Cancer Cell. 2019;35(4):573-587.
10.1016/j.ccell.2019.03.002
1878-3686
15356108
Cancer cell
30975481
http://hdl.handle.net/20.500.12105/8310
Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant percentage of PDAC tumors driven by Kras/Trp53 mutations in genetically engineered mice. Moreover, systemic elimination of these targets induces toxicities that are well tolerated. Response to this targeted therapy correlates with transcriptional profiles that resemble those observed in human PDACs. Finally, inhibition of EGFR and c-RAF expression effectively blocked tumor progression in nine independent patient-derived xenografts carrying KRAS and TP53 mutations. These results open the door to the development of targeted therapies for PDAC patients.
eng
Cdk4
EGFR
Erlotinib
PDX tumor models
Pancreatic cancer
c-Raf
Therapeutic mouse models
Transcriptional profiles
Tumor regression
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF
journal article
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URL
https://repisalud.isciii.es/bitstreams/3c6cb14c-a09d-467c-b896-5f8768b08f97/download
File
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application/pdf
CompleteRegressionofAdvancedPancreaticDUCTAL_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/8a618b62-422f-4953-81ed-99c349e6ecca/download
File
MD5
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text/plain
CompleteRegressionofAdvancedPancreaticDUCTAL_2019.pdf.txt