2026-06-30T02:51:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/82472025-05-07T10:46:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rodero, Laura
author
Mellado, Emilia
author
Rodríguez, A Carolina
author
Salve, Angela
author
Guelfand, Liliana
author
Cahn, Pedro
author
Cuenca-Estrella, Manuel
author
Davel, Graciela
author
Rodriguez-Tudela, Juan Luis
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
2019-08-13T12:22:21Z
2019-08-13T12:22:21Z
2003-11
Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6.
10.1128/aac.47.11.3653-3656.2003
0066-4804
Antimicrobial agents and chemotherapy
14576140
http://hdl.handle.net/20.500.12105/8247
Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S.
eng
G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate
research article
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G484SAminoAcidSubstitution_2003.pdf
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G484SAminoAcidSubstitution_2003_Figure1.pdf
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G484SAminoAcidSubstitution_2003_Figure2.pdf
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G484SAminoAcidSubstitution_2003.pdf.txt
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G484SAminoAcidSubstitution_2003_Figure1.pdf.txt
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