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oai:repisalud.isciii.es:20.500.12105/82472025-05-07T10:46:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Rodero, Laura author Mellado, Emilia author Rodríguez, A Carolina author Salve, Angela author Guelfand, Liliana author Cahn, Pedro author Cuenca-Estrella, Manuel author Davel, Graciela author Rodriguez-Tudela, Juan Luis author 2003-11 Five sequential Cryptococcus neoformans isolates recovered from an AIDS patient with recurrent meningitis were analyzed. Four isolates were fluconazole susceptible, while the fifth isolate developed fluconazole resistance. Analysis of the 14-alpha lanosterol demethylase gene (ERG11) showed a point mutation in the resistant strain responsible for the amino acid substitution G484S. Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6. 10.1128/aac.47.11.3653-3656.2003 0066-4804 Antimicrobial agents and chemotherapy 14576140 http://hdl.handle.net/20.500.12105/8247 G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate