2026-06-14T03:28:55Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/82382024-09-27T21:46:27Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Balsalobre-Arenas, Maria Luz
author
Ferrandiz-Avellano, Maria-Jose
author
Liñares, Josefina
author
Tubau, Fe
author
de la Campa, Adela G
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia y Tecnología (España)
2019-08-13T12:10:37Z
2019-08-13T12:10:37Z
2003-07
Antimicrob Agents Chemother. 2003 Jul;47(7):2072-81
10.1128/aac.47.7.2072-2081.2003
0066-4804
Antimicrobial agents and chemotherapy
12821449
http://hdl.handle.net/20.500.12105/8238
A total of 46 ciprofloxacin-resistant (Cip(r)) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cip(r) isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae.
eng
Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae
journal article
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