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oai:repisalud.isciii.es:20.500.12105/82382024-09-27T21:46:27Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Balsalobre-Arenas, Maria Luz author Ferrandiz-Avellano, Maria-Jose author Liñares, Josefina author Tubau, Fe author de la Campa, Adela G author 2003-07 A total of 46 ciprofloxacin-resistant (Cip(r)) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC, parE, and gyrA genes. The nucleotide sequence of the full-length parC, parE, and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant-like gene in the intergenic parE-parC regions of the S. pneumoniae Cip(r) isolates with high rates of variations in their parE and parC QRDRs. The ant-like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE-parC regions of the viridans group streptococci (Streptococcus mitis and Streptococcus oralis). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae. Antimicrob Agents Chemother. 2003 Jul;47(7):2072-81 10.1128/aac.47.7.2072-2081.2003 0066-4804 Antimicrobial agents and chemotherapy 12821449 http://hdl.handle.net/20.500.12105/8238 Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae