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oai:repisalud.isciii.es:20.500.12105/82352024-09-27T21:40:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc de la Campa, Adela G author Ferrandiz-Avellano, Maria-Jose author Tubau, Fe author Pallarés, Román author Manresa, Federico author Liñares, Josefina author 2003-04 Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants. Antimicrob Agents Chemother. 2003 Apr;47(4):1419-22. 10.1128/aac.47.4.1419-1422.2003 0066-4804 Antimicrobial agents and chemotherapy 12654682 http://hdl.handle.net/20.500.12105/8235 Genetic characterization of fluoroquinolone-resistant Streptococcus pneumoniae strains isolated during ciprofloxacin therapy from a patient with bronchiectasis