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oai:repisalud.isciii.es:20.500.12105/82062024-11-29T17:21:14Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Tapial, Sandra author Olmedillas-López, Susana author Rueda, Daniel author Arriba, María author García, Juan L author Vivas, Alfredo author Pérez, Jessica author Pena-Couso, Laura author Olivera, Rocío author Rodríguez, Yolanda author García-Arranz, Mariano author García-Olmo, Damián author González-Sarmiento, Rogelio author Urioste, Miguel author Goel, Ajay author Perea, José author 2019-07-19 Colorectal cancer (CRC) with CpG island methylator phenotype (CIMP) is recognized as a subgroup of CRC that shows association with particular genetic defects and patient outcomes. We analyzed CIMP status of 229 individuals with CRC using an eight-marker panel (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1); CIMP-(+) tumors were defined as having ≥ 5 methylated markers. Patients were divided into individuals who developed a "unique" CRC, which were subclassified into early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and patients with multiple primary CRCs subclassified into synchronous CRC (SCRC) and metachronous CRC (MCRC). We found 9 (15.2%) CIMP-(+) EOCRC patients related with the proximal colon (p = 0.008), and 19 (26.8%) CIMP-(+) LOCRC patients associated with tumor differentiation (p = 0.045), MSI status (p = 0.021) and BRAF mutation (p = 0.001). Thirty-five (64.8%) SCRC patients had at least one CIMP-(+) tumor and 20 (44.4%) MCRC patients presented their first tumor as CIMP-(+). Thirty-nine (72.2%) SCRC patients showed concordant CIMP status in their simultaneous tumors. The differences in CIMP-(+) frequency between groups may reflect the importance of taking into account several criteria for the development of multiple primary neoplasms. Additionally, the concordance between synchronous tumors suggests CIMP status is generally maintained in SCRC patients. Sci Rep. 2019 ;9(1):10516. 10.1038/s41598-019-47014-w 2045-2322 2045-2322 Scientific reports 31324877 http://hdl.handle.net/20.500.12105/8206 ISLAND METHYLATOR PHENOTYPE MARKERS MICROSATELLITE INSTABILITY CHROMOSOMAL INSTABILITY FIELD CANCERIZATION BRAF MUTATION COLON PATHWAY CLASSIFICATION THERAPY Cimp-Positive Status is More Representative in Multiple Colorectal Cancers than in Unique Primary Colorectal Cancers