2026-06-14T06:44:25Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79902024-09-27T08:04:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Gómez-Gaviro, Maria Victoria
author
Lovell-Badge, Robin
author
Fernández-Avilés, Francisco
author
Lara-Pezzi, Enrique
2019-07-30T08:33:56Z
2019-07-30T08:33:56Z
2012-10
J Cardiovasc Transl Res. 2012; 5(5):618-30
10.1007/s12265-012-9371-x
1937-5395
1937-5387
Journal of cardiovascular translational research
22644724
http://hdl.handle.net/20.500.12105/7990
Stem cells in adult organs reside in specialized niches that regulate their proliferation and differentiation. Investigations during the last few years have unveiled a regulatory role for blood vessels in these microenvironments. Mesenchymal stem cells (MSCs) are located surrounding capillaries in a variety of tissues and have the capacity to differentiate into different mesodermal lineages. Angiogenic progenitor cells have also been found in the adventitial layer of large vessels. In the bone marrow, endothelial cells control hematopoietic stem cell (HSC) release, and in the brain, blood vessels regulate neural stem cell (NSC) self-renewal and neurogenesis. Similarly, perivascular progenitor cells have also been found in the heart. This intimate connection between stem cells and the vasculature contributes to tissue homeostasis and repair. In this review, we focus on the regulation of stem and progenitor cells in different adult niches by blood vessels and the few mechanisms that are known to mediate this interaction.
eng
The vascular stem cell niche
journal article
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URL
https://repisalud.isciii.es/bitstreams/60d78db4-38e2-4a45-b6d3-b5d389173d29/download
File
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application/pdf
VascularStemCellNiche_2012.pdf
URL
https://repisalud.isciii.es/bitstreams/4b88b80f-8b8a-429a-8c4a-831ca904c5b9/download
File
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text/plain
VascularStemCellNiche_2012.pdf.txt