2026-04-29T04:09:03Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79772025-06-12T15:09:20Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608col_20.500.12105_19611
Repisalud
author
Herrador, Zaida
author
Fernandez Martinez, Beatriz
author
Quesada-Cubo, Víctor
author
Diaz Garcia, Maria Oliva
author
Cano-Portero, Rosa
author
Benito, Agustin
author
Gomez-Barroso, Diana
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-07-29T10:48:58Z
2019-07-29T10:48:58Z
2019-07-10
Malar J. 2019 Jul 10;18(1):230.
1475-2875
http://hdl.handle.net/20.500.12105/7977
31291951
10.1186/s12936-019-2863-2
1475-2875
Malaria journal
BACKGROUND: Malaria was eliminated in Spain in 1964. Since then, more than 10,000 cases of malaria have been reported, mostly in travellers and migrants, making it the most frequently imported disease into this country. In order to improve knowledge on imported malaria cases characteristics, the two main malaria data sources were assessed: the national surveillance system and the hospital discharge database (CMBD). METHODS: Observational study using prospectively gathered surveillance data and CMBD records between 2002 and 2015. The average number of hospitalizations per year was calculated to assess temporal patterns. Socio-demographic, clinical and travel background information were analysed. Bivariate and multivariable statistical methods were employed to evaluate hospitalization risk, fatal outcome, continent of infection and chemoprophylaxis failure and their association with different factors. RESULTS: A total of 9513 malaria hospital discharges and 7421 reported malaria cases were identified. The number of reported cases was below the number of hospitalizations during the whole study period, with a steady increase trend in both databases since 2008. Males aged 25-44 were the most represented in both data sources. Most frequent related co-diagnoses were anaemia (20.2%) and thrombocytopaenia (15.4%). The risks of fatal outcome increased with age and were associated with the parasite species (Plasmodium falciparum). The main place of infection was Africa (88.9%), particularly Equatorial Guinea (33.2%). Most reported cases were visiting friends and relatives (VFRs) and immigrants (70.2%). A significant increased likelihood of hospitalization was observed for children under 10 years (aOR:2.7; 95% CI 1.9-3.9), those infected by Plasmodium vivax (4.3; 95% CI 2.1-8.7) and travellers VFRs (1.4; 95% CI 1.1-1.7). Only 4% of cases reported a correct regime of chemoprophylaxis. Being male, over 15 years, VFRs, migrant and born in an endemic country were associated to increased risk of failure in preventive chemotherapy. CONCLUSIONS: The joint analysis of two data sources allowed for better characterization of imported malaria profile in Spain. Despite the availability of highly effective preventive measures, the preventable burden from malaria is high in Spain. Pre-travel advice and appropriately delivered preventive messages needs to be improved, particularly in migrants and VFRs.
eng
Imported malaria
Malaria
Malaria chemoprophylaxis
Non-endemic areas
Spain
Imported cases of malaria in Spain: observational study using nationally reported statistics and surveillance data, 2002-2015
research article
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URL
https://repisalud.isciii.es/bitstreams/5056fdd7-684f-4a72-9462-0a85dc8da7c9/download
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ImportedCasesOfMalaria_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/14a85315-7363-4cb9-931b-2884f5fb8ff3/download
File
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text/plain
ImportedCasesOfMalaria_2019.pdf.txt