2026-07-17T13:31:45Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79682024-09-27T08:41:38Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lara-Pezzi, Enrique
author
Desco, Manuel
author
Gatto, Alberto
author
Gómez-Gaviro, María Victoria
funder
Unión Europea. Comisión Europea
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación ProCNIC
2019-07-26T14:22:05Z
2019-07-26T14:22:05Z
2017-10
Neuroscientist. 2017; 23(5):466-77
10.1177/1073858416678604
1089-4098
1073-8584
The Neuroscientist
27837180
http://hdl.handle.net/20.500.12105/7968
The complexity of the mammalian brain requires highly specialized protein function and diversity. As neurons differentiate and the neuronal circuitry is established, several mRNAs undergo alternative splicing and other posttranscriptional changes that expand the variety of protein isoforms produced. Recent advances are beginning to shed light on the molecular mechanisms that regulate isoform switching during neurogenesis and the role played by specific RNA binding proteins in this process. Neurogenesis and neuronal wiring were recently shown to also be regulated by RNA degradation through nonsense-mediated decay. An additional layer of regulatory complexity in these biological processes is the interplay between alternative splicing and long noncoding RNAs. Dysregulation of posttranscriptional regulation results in defective neuronal differentiation and/or synaptic connections that lead to neurodevelopmental and psychiatric disorders.
eng
alternative splicing
molecular neurology
molecular psychiatry
neurogenesis
noncoding RNAs
nonsense-mediated decay
Neurogenesis: Regulation by Alternative Splicing and Related Posttranscriptional Processes
journal article
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NeurogenesisRegulationAlternativeSplicing_2017.pdf.txt