2026-06-14T05:05:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79672024-09-27T08:48:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
del Campo, Lara
author
Hamczyk, Magda R.
author
Andres, Vicente
author
Martinez-Gonzalez, Jose
author
Rodriguez, Cristina
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación La Marató TV3
funder
Progeria Research Foundation
funder
Centro de Investigación Biomedica en Red - CIBER
funder
Fundación ProCNIC
2019-07-19T13:24:46Z
2019-07-19T13:24:46Z
2018-06
Clin Investig Arterioscler. 2018; 30(3):120-32
10.1016/j.arteri.2017.12.007
1578-1879
02149168
Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
29602596
http://hdl.handle.net/20.500.12105/7967
Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD. This mutant form of prelamin A induces generalised atherosclerosis, vascular calcification, and cardiac electrophysiological abnormalities, leading to premature aging and death, mainly due to myocardial infarction and stroke. This review discusses the main vascular structural and functional abnormalities during physiological and premature aging, as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. Both proteins are expressed in non-HGPS individuals, and physiological aging shares many features of progeria. Research into HGPS could therefore shed light on novel mechanisms involved in the physiological aging of the cardiovascular system.
spa
Aterosclerosis
Atherosclerosis
Calcificación vascular
Cardiovascular disease
Enfermedad cardiovascular
Prelamin A/lamin A
Prelamina A/lamina A
Progerin
Progerina
Vascular calcification
Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?
journal article
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MechanismsOfVascularAging_2018.pdf
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MechanismsOfVascularAging_2018.pdf.txt