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oai:repisalud.isciii.es:20.500.12105/79672024-09-27T08:48:22Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc del Campo, Lara author Hamczyk, Magda R. author Andres, Vicente author Martinez-Gonzalez, Jose author Rodriguez, Cristina author 2018-06 Aging is the main risk factor for cardiovascular disease (CVD). The increased prevalence of CVD is partly due to the global increase in life expectancy. In this context, it is essential to identify the mechanisms by which aging induces CVD, with the ultimate aim of reducing its incidence. Both atherosclerosis and heart failure significantly contribute to age-associated CVD morbidity and mortality. Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by the synthesis of progerin, which is noted for accelerated aging and CVD. This mutant form of prelamin A induces generalised atherosclerosis, vascular calcification, and cardiac electrophysiological abnormalities, leading to premature aging and death, mainly due to myocardial infarction and stroke. This review discusses the main vascular structural and functional abnormalities during physiological and premature aging, as well as the mechanisms involved in the exacerbated CVD and accelerated aging induced by the accumulation of progerin and prelamin A. Both proteins are expressed in non-HGPS individuals, and physiological aging shares many features of progeria. Research into HGPS could therefore shed light on novel mechanisms involved in the physiological aging of the cardiovascular system. Clin Investig Arterioscler. 2018; 30(3):120-32 10.1016/j.arteri.2017.12.007 1578-1879 02149168 Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 29602596 http://hdl.handle.net/20.500.12105/7967 Aterosclerosis Atherosclerosis Calcificación vascular Cardiovascular disease Enfermedad cardiovascular Prelamin A/lamin A Prelamina A/lamina A Progerin Progerina Vascular calcification Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome?