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oai:repisalud.isciii.es:20.500.12105/79662024-09-27T09:21:33Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Hamczyk, Magda R. author del Campo, Lara author Andres, Vicente author 2018-02 Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively more prevalent in our societies. A better understanding of how aging promotes CVD is therefore urgently needed to develop new strategies to reduce disease burden. Atherosclerosis and heart failure contribute significantly to age-associated CVD-related morbimortality. CVD and aging are both accelerated in patients suffering from Hutchinson-Gilford progeria syndrome (HGPS), a rare genetic disorder caused by the prelamin A mutant progerin. Progerin causes extensive atherosclerosis and cardiac electrophysiological alterations that invariably lead to premature aging and death. This review summarizes the main structural and functional alterations to the cardiovascular system during physiological and premature aging and discusses the mechanisms underlying exaggerated CVD and aging induced by prelamin A and progerin. Because both proteins are expressed in normally aging non-HGPS individuals, and most hallmarks of normal aging occur in progeria, research on HGPS can identify mechanisms underlying physiological aging. Annu Rev Physiol. 2018; 80:27-48 10.1146/annurev-physiol-021317-121454 1545-1585 0066-4278 Annual review of physiology 28934587 http://hdl.handle.net/20.500.12105/7966 Atherosclerosis Cardiovascular disease Heart failure Prelamin A/lamin A Progerin Vascular calcification Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome