2026-08-29T09:24:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79592024-09-27T08:23:11Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Dorado, Beatriz
author
Andres, Vicente
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Fundación La Marató TV3
funder
Progeria Research Foundation
funder
Fundación ProCNIC
2019-07-19T08:47:19Z
2019-07-19T08:47:19Z
2017
Curr Opin Cell Biol. 2017; 46:17-25
10.1016/j.ceb.2016.12.005
1879-0410
0955-0674
Current opinion in cell biology
28086161
http://hdl.handle.net/20.500.12105/7959
Lamin A is a nuclear intermediate filament protein with important structural and regulatory roles in most differentiated mammalian cells. Excessive accumulation of its precursor prelamin A or the mutant form called 'progerin' causes premature aging syndromes. Progeroid 'laminopathies' are characterized by severe cardiovascular problems (cardiac electrical defects, vascular calcification and stiffening, atherosclerosis, myocardial infarction, and stroke) and premature death. Here, we review studies in cell and mouse models and patients that are unraveling how abnormal prelamin A and progerin accumulation accelerates cardiovascular disease and aging. This knowledge is essential for developing effective therapies to treat progeria and may help identify new mechanisms underlying normal aging.
eng
A-type lamins and cardiovascular disease in premature aging syndromes
journal article
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URL
https://repisalud.isciii.es/bitstreams/a524607c-1437-49d9-82f8-044a1a4f8393/download
File
MD5
217a02e2134dd2a235dab79739da35a5
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application/pdf
A-typeLaminsCardiovascularDisease_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/a6bb1150-95db-47c9-860b-bd32b2823483/download
File
MD5
d98b0642a420e2f928ed5c7b8a436a61
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text/plain
A-typeLaminsCardiovascularDisease_2017.pdf.txt