2026-06-14T03:28:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/79002025-05-07T10:12:53Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Galindo-Albarrán, Ariel O
author
López-Portales, Oscar H
author
Gutiérrez-Reyna, Darely Y
author
Rodríguez-Jorge, Otoniel
author
Sánchez-Villanueva, José Antonio
author
Ramírez-Pliego, Oscar
author
Bergon, Aurélie
author
Loriod, Béatrice
author
Holota, Hélène
author
Imbert, Jean
author
Hernández-Mendoza, Armando
author
Ferrier, Pierre
author
Carrillo-de-Santa-Pau, Enrique
author
Valencia, Alfonso
author
Spicuglia, Salvatore
author
Santana, M Angélica
funder
Consejo Nacional de Ciencia y Tecnología (México)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Programa de Mejoramiento del Profesorado
funder
Aix-Marseille University (Francia)
funder
Fondation ARC pour la recherche sur le cancer
2019-07-12T09:31:22Z
2019-07-12T09:31:22Z
2016-11-15
Cell Rep. 2016;17(8):2151-2160.
10.1016/j.celrep.2016.10.056
2211-1247
22111247
Cell reports
27851975
http://hdl.handle.net/20.500.12105/7900
To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.
eng
T lymphocyte
Epigenome
Human immunity
Immune response
CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response
journal article
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
URL
https://repisalud.isciii.es/bitstreams/cf18457c-0060-412b-b718-8be8bcf6fbd7/download
File
MD5
3c4ae2cd962705a89e0f61c441fb2af5
2257283
application/pdf
CD8+TCellsfromHumanNeonates_2016.pdf
URL
https://repisalud.isciii.es/bitstreams/3abdf194-fd39-4509-8bfc-3328f3142a01/download
File
MD5
fbadf6e1ac459496860d19a516587758
10882684
application/pdf
CD8+TCellsfromHumanNeonates_2016_supl1.pdf
URL
https://repisalud.isciii.es/bitstreams/63834929-5101-4ca8-a826-d9c45409728c/download
File
MD5
2fb10b6b7dd7a85d3e69df5f4dd560ee
12001
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
CD8+TCellsfromHumanNeonates_table1_2016.xlsx
URL
https://repisalud.isciii.es/bitstreams/4eff484a-49d6-49ff-a443-e98bf85d2377/download
File
MD5
1f7d6baadfe347d20cb945899f72dda7
10064069
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
CD8+TCellsfrom HumanNeonates_2016_table2.xlsx
URL
https://repisalud.isciii.es/bitstreams/087ea4ec-dca4-4625-a091-a93c2cd21dc0/download
File
MD5
d37e8fb8fb107a3394b0ac9009a81170
104945
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
CD8+TCellsfromHumanNeonates_2016_table4.xlsx
URL
https://repisalud.isciii.es/bitstreams/ac9a51cc-0813-4aeb-8b08-b5294799ec05/download
File
MD5
24b56a95736b6d624d044d66a565c3ab
13133116
application/pdf
CD8+TCellsfromHumanNeonates_2016.table5.pdf
URL
https://repisalud.isciii.es/bitstreams/12b8d749-8a23-49c6-9ef6-62db3cef2eea/download
File
MD5
a2f6a19a0912a95e873aab9b10060658
60933
text/plain
CD8+TCellsfromHumanNeonates_2016.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/a56e4d72-549f-4316-ab68-e6c035465ae0/download
File
MD5
2e71bd87de5c2a2743bf9d241529f574
13011
text/plain
CD8+TCellsfromHumanNeonates_2016_supl1.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/475974b1-598a-4321-a9db-3622e6c7c704/download
File
MD5
d3b0a3ca3eb10f2360895018d63ec6a6
73944
text/plain
CD8+TCellsfromHumanNeonates_2016.table5.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/f0b7c0a2-a3bd-481c-9ccb-1cf26243fdfa/download
File
MD5
6e5366acb87cac1df8589ba9fe49b958
16208
text/plain
CD8+TCellsfromHumanNeonates_table1_2016.xlsx.txt
URL
https://repisalud.isciii.es/bitstreams/a3e0fb6a-409a-494d-9733-38967b49a74b/download
File
MD5
3567845d8cbdf48682067336fd880ec4
100000
text/plain
CD8+TCellsfrom HumanNeonates_2016_table2.xlsx.txt
URL
https://repisalud.isciii.es/bitstreams/0014c368-0631-4c57-9fe1-458b10e3e88f/download
File
MD5
f55dead66d32151779d02936a3781089
100000
text/plain
CD8+TCellsfromHumanNeonates_2016_table4.xlsx.txt