2026-06-14T03:30:11Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/79002025-05-07T10:12:53Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Galindo-Albarrán, Ariel O author López-Portales, Oscar H author Gutiérrez-Reyna, Darely Y author Rodríguez-Jorge, Otoniel author Sánchez-Villanueva, José Antonio author Ramírez-Pliego, Oscar author Bergon, Aurélie author Loriod, Béatrice author Holota, Hélène author Imbert, Jean author Hernández-Mendoza, Armando author Ferrier, Pierre author Carrillo-de-Santa-Pau, Enrique author Valencia, Alfonso author Spicuglia, Salvatore author Santana, M Angélica author 2016-11-15 To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8+ T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8+ T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8+ T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response. Cell Rep. 2016;17(8):2151-2160. 10.1016/j.celrep.2016.10.056 2211-1247 22111247 Cell reports 27851975 http://hdl.handle.net/20.500.12105/7900 T lymphocyte Epigenome Human immunity Immune response CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response