2026-06-14T03:38:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78992025-05-05T12:13:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Leon-Espinosa, Gonzalo
author
Sanchez-Ruiloba, Lucia
author
Perez-Rodriguez, Andrea
author
Gragera, Teresa
author
Martinez, Natalia
author
Hernandez, Silvia
author
Anta-Felez, Berta
author
Calero, Olga
author
Garcia-Dominguez, Carlota A
author
Dura, Lara M
author
Peña-Jimenez, Daniel
author
Castro, Judith
author
Zarich-Dimitrievich, Natasha
author
Sánchez-Gómez, Pilar
author
Calero, Miguel
author
Iglesias, Teresa
author
Oliva-Martinez, Jose Luis
author
Rojas-Cabañeros, Jose Maria
funder
Asociación Española Contra el Cáncer
funder
Ministerio de Educación y Ciencia (España)
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERNED (Enfermedades Neurodegenerativas)
funder
Comunidad de Madrid (España)
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Asociación Española Contra el Cáncer
2019-07-12T08:31:12Z
2019-07-12T08:31:12Z
2014
PLoS One. 2014 Dec 16;9(12):e114837
10.1371/journal.pone.0114837
1932-6203
1932-6203
PLoS ONE
25514808
http://hdl.handle.net/20.500.12105/7899
The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth.
eng
Shoc2/Sur8 Protein Regulates Neurite Outgrowth
research article
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URL
https://repisalud.isciii.es/bitstreams/9a064581-6590-4dd1-a576-025e7e09bdbd/download
File
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application/pdf
Shoc2_Sur8_Protein_Regulates_2014.pdf
URL
https://repisalud.isciii.es/bitstreams/72150642-a22c-43b3-bf1a-9b55ccff99c6/download
File
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text/plain
Shoc2_Sur8_Protein_Regulates_2014.pdf.txt