2026-04-29T07:23:41Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78982025-06-13T09:57:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Fernández-Martínez, P
author
Zahonero, Cristina
author
Sánchez-Gómez, Pilar
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
2019-07-12T07:53:54Z
2019-07-12T07:53:54Z
2015
Molecular & Cellular Oncology, 2:1, e970048
2372-3556
http://hdl.handle.net/20.500.12105/7898
27308401
10.4161/23723548.2014.970048
Molecular & Cellular Oncology
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors. The DYRK1A gene is located in the Down syndrome critical region and may play a significant role in the developmental brain defects, early neurodegeneration, and cancer susceptibility of individuals with this syndrome. DYRK1A is also expressed in adults, where it might participate in the regulation of cell cycle, survival, and tumorigenesis, thus representing a potential therapeutic target for certain types of cancer. However, the final readout of DYRK1A overexpression or inhibition depends strongly on the cellular context, as it has both tumor suppressor and oncogenic activities. Here, we will discuss the functions and substrates of DYRK1A associated with the control of cell growth and tumorigenesis with a focus on the potential use of DYRK1A inhibitors in cancer therapy.
eng
DYRK1A
Cancer
Cell differentiation
Cell proliferation
Neural progenitors
DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis
research article
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URL
https://repisalud.isciii.es/bitstreams/896afd37-3465-4c8f-b87c-33db150d1ac4/download
File
MD5
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application/pdf
DYRK1_DoubleEdgedKinase_2015.pdf
URL
https://repisalud.isciii.es/bitstreams/2e56ed0a-e740-4340-b221-18c8694a39d7/download
File
MD5
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text/plain
DYRK1_DoubleEdgedKinase_2015.pdf.txt