2026-04-29T07:24:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78982025-06-13T09:57:19Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Fernández-Martínez, P author Zahonero, Cristina author Sánchez-Gómez, Pilar author 2015 DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors. The DYRK1A gene is located in the Down syndrome critical region and may play a significant role in the developmental brain defects, early neurodegeneration, and cancer susceptibility of individuals with this syndrome. DYRK1A is also expressed in adults, where it might participate in the regulation of cell cycle, survival, and tumorigenesis, thus representing a potential therapeutic target for certain types of cancer. However, the final readout of DYRK1A overexpression or inhibition depends strongly on the cellular context, as it has both tumor suppressor and oncogenic activities. Here, we will discuss the functions and substrates of DYRK1A associated with the control of cell growth and tumorigenesis with a focus on the potential use of DYRK1A inhibitors in cancer therapy. Molecular & Cellular Oncology, 2:1, e970048 2372-3556 http://hdl.handle.net/20.500.12105/7898 27308401 10.4161/23723548.2014.970048 Molecular & Cellular Oncology DYRK1A Cancer Cell differentiation Cell proliferation Neural progenitors DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis