2026-06-14T05:17:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78952025-05-09T09:24:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Villanueva, Andrea A
author
Puvogel, Sofía
author
Lois, Pablo
author
Muñoz-Palma, Ernesto
author
Ramírez Orellana, Manuel
author
Lubieniecki, Fabiana
author
Casco Claro, Fernando
author
Gallegos, Iván
author
Garcia-Castro, Javier
author
Sánchez-Gómez, Pilar
author
Torres, Vicente A
author
Palma, Verónica
funder
Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
funder
Comisión Nacional de Investigación Científica y Tecnológica (Chile)
2019-07-11T10:38:40Z
2019-07-11T10:38:40Z
2018
Cell Adh Migr. 2019 Dec;13(1):33-40
10.1080/19336918.2018.1506652
1933-6926
1933-6918
Cell Adhesion & Migration
30160193
http://hdl.handle.net/20.500.12105/7895
Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.
eng
Laminin γ1
Neogenin-1
Netrin-4
Neuroblastoma
Basal lamina
Cell adhesion
Cell migration
The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells
research article
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URL
https://repisalud.isciii.es/bitstreams/ab6115b5-6aa3-4af3-ba63-258d7444ad54/download
File
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application/pdf
Netrin-4_Laminin γ1_Neogenin-1_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/0082d4d8-839c-41ee-af21-480eb4e1b2dc/download
File
MD5
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text/plain
Netrin-4_Laminin γ1_Neogenin-1_2019.pdf.txt