2026-06-14T05:17:39Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78952025-05-09T09:24:24Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Villanueva, Andrea A author Puvogel, Sofía author Lois, Pablo author Muñoz-Palma, Ernesto author Ramírez Orellana, Manuel author Lubieniecki, Fabiana author Casco Claro, Fernando author Gallegos, Iván author Garcia-Castro, Javier author Sánchez-Gómez, Pilar author Torres, Vicente A author Palma, Verónica author 2018 Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells. Cell Adh Migr. 2019 Dec;13(1):33-40 10.1080/19336918.2018.1506652 1933-6926 1933-6918 Cell Adhesion & Migration 30160193 http://hdl.handle.net/20.500.12105/7895 Laminin γ1 Neogenin-1 Netrin-4 Neuroblastoma Basal lamina Cell adhesion Cell migration The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells