2026-06-14T05:06:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78902025-05-07T10:14:03Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Juan, David author Perner, Juliane author Carrillo-de-Santa-Pau, Enrique author Marsili, Simone author Ochoa, David author Chung, Ho-Ryun author Vingron, Martin author Rico, Daniel author Valencia, Alfonso author 2016-02-09 Epigenetic communication through histone and cytosine modifications is essential for gene regulation and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifications in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of pluripotency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chromatin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or metabolism. Our results highlight the importance of cytosine modifications in the epigenetic communication of ESCs. Cell Rep. 2016;14(5):1246-1257 10.1016/j.celrep.2016.01.008 2211-1247 22111247 Cell reports 26832418 http://hdl.handle.net/20.500.12105/7890 Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs