2026-06-30T02:01:44Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78782024-11-29T16:36:37Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Petruzzelli, Michele author Wagner, Erwin Friedrich author 2016-03-01 Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the adipose tissue. This systemic syndrome, termed cancer-associated cachexia (CAC), is a major cause of morbidity and mortality. While once attributed solely to decreased food intake, the present description of cancer cachexia is a disorder of multiorgan energy imbalance. Here we review the molecules and pathways responsible for metabolic dysfunction in CAC and the ideas that led to the current understanding. Genes Dev. 2016;30(5):489-501. 10.1101/gad.276733.115 1549-5477 0890-9369 Genes & development 26944676 http://hdl.handle.net/20.500.12105/7878 cancer-associated cachexia (CAC) metabolic failure skeletal muscle atrophy white adipose tissue (WAT) browning Mechanisms of metabolic dysfunction in cancer-associated cachexia