2026-08-29T15:33:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78702024-11-30T00:57:10Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
LLanos, Susana
author
García-Pedrero, Juana M
author
Morgado-Palacin, Lucia
author
Rodrigo, Juan P
author
Serrano Marugan, Manuel
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Botín Foundation
funder
Fundación Ramón Areces
funder
Fundación AXA
funder
Ministerio de Economía y Competitividad (España)
2019-07-08T11:43:27Z
2019-07-08T11:43:27Z
2016-02-02
Nat Commun. 2016;7:10438.
10.1038/ncomms10438
2041-1723
2041-1723
Nature communications
26832959
http://hdl.handle.net/20.500.12105/7870
The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation. Accordingly, hyper-activation of mTORC1 results in phosphorylation of 4E-BP1 and stabilization of p21. In HNSCC, p21 levels strongly correlate with mTORC1 activity but not with p53 status. Finally, clinical data indicate that HNSCC patients with p21 and phospho-S6-double-positive tumours present a better disease-specific survival. We conclude that over-activation of the mTORC1/4E-BP1/p21 pathway is a frequent and clinically relevant alteration in HNSCC.
eng
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
journal article
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