2026-08-29T16:26:33Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78702024-11-30T00:57:10Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc LLanos, Susana author García-Pedrero, Juana M author Morgado-Palacin, Lucia author Rodrigo, Juan P author Serrano Marugan, Manuel author 2016-02-02 The levels, regulation and prognostic value of p21 in head and neck squamous cell carcinomas (HNSCC) has been puzzling for years. Here, we report a new mechanism of regulation of p21 by the mTORC1/4E-BP1 pathway. We find that non-phosphorylated 4E-BP1 interacts with p21 and induces its degradation. Accordingly, hyper-activation of mTORC1 results in phosphorylation of 4E-BP1 and stabilization of p21. In HNSCC, p21 levels strongly correlate with mTORC1 activity but not with p53 status. Finally, clinical data indicate that HNSCC patients with p21 and phospho-S6-double-positive tumours present a better disease-specific survival. We conclude that over-activation of the mTORC1/4E-BP1/p21 pathway is a frequent and clinically relevant alteration in HNSCC. Nat Commun. 2016;7:10438. 10.1038/ncomms10438 2041-1723 2041-1723 Nature communications 26832959 http://hdl.handle.net/20.500.12105/7870 Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers