2026-05-16T22:10:10Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78492024-09-27T09:08:24Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cossio, Itziar
author
Lucas, Daniel
author
Hidalgo, Andres
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
National Institutes of Health (Estados Unidos)
funder
Fundación ProCNIC
2019-07-03T14:11:16Z
2019-07-03T14:11:16Z
2019-05
Blood. 2019; 133(20):2140-2148
10.1182/blood-2018-10-844571
1528-0020
0006-4971
Blood
30898859
http://hdl.handle.net/20.500.12105/7849
The niche that supports hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is a highly dynamic structure. It maintains core properties of HSPCs in the steady state, and modulates their proliferation and differentiation in response to changing physiological demands or pathological insults. The dynamic and environment-sensing properties of the niche are shared by the innate immune system. Thus, it is not surprising that innate immune cells, including macrophages and neutrophils, are now recognized as important regulators of the hematopoietic niche and, ultimately, of the stem cells from which they derive. This review synthesizes emerging concepts on niche regulation by immune cells, with a particular emphasis on neutrophils. We argue that the unique developmental, circadian, and migratory properties of neutrophils underlie their critical contributions as regulators of the hematopoietic niche.
eng
Neutrophils as regulators of the hematopoietic niche
journal article
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URL
https://repisalud.isciii.es/bitstreams/53dbf6e8-d844-4f97-bbf0-a088c0f98d0e/download
File
MD5
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application/pdf
NeutrophilsRegulatorsHematopoieticNiche_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/d95da17b-cadd-47e0-afcd-5d0e5b4b17f6/download
File
MD5
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text/plain
NeutrophilsRegulatorsHematopoieticNiche_2019.pdf.txt