2026-04-29T12:22:45Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78482024-09-27T10:15:32Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607

00925njm 22002777a 4500 dc Riobóo, Rafael J. Jiménez author Desco, Manuel author Gómez-Gaviro, María Victoria author 2019-06 Brillouin spectroscopy is a well-established technology in condensed matter physics to characterize the mechanical properties of inert materials, and it has been extended very recently to the study of biological samples. Transparency is beneficial for samples to be properly analyzed by Brillouin spectroscopy. Here, we explored the efficacy of optical tissue clearing techniques to improve the acquisition of Brillouin spectra from biological tissues in order to analyze their biomechanical properties. We describe the first application of Brillouin scattering to optically cleared biological tissues with CUBIC protocol. We conclude that, within the range of error, tissue clearing does not modify the mechanical properties of the studied biological tissues. Biomed Opt Express. 2019; 10(6):2674-2683 10.1364/BOE.10.002674 2156-7085 Biomedical Optics Express 31259043 http://hdl.handle.net/20.500.12105/7848 Impact of optical tissue clearing on the Brillouin signal from biological tissue samples