2026-04-30T10:43:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78362024-11-28T14:57:23Zcom_20.500.12105_2173com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19597col_20.500.12105_16927col_20.500.12105_16962
Repisalud
author
Nombela, Paz
author
Lozano, Rebeca
author
Aytes, Alvaro
author
Mateo, Joaquin
author
Olmos, David
author
Castro, Elena
funder
Instituto de Salud Carlos III
funder
European Association of Urology
funder
Fundación BBVA
funder
United States Department of Defense
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-07-02T08:33:22Z
2019-07-02T08:33:22Z
2019-03-12
Cancers (Basel). 2019;11(3). pii: E352
10.3390/cancers11030352
2072-6694
Cancers
http://hdl.handle.net/10668/13709
30871108
http://hdl.handle.net/20.500.12105/7836
Germline and somatic aberrations in DNA damage repair (DDR) genes are more prevalent in prostate cancer than previously recognized, with BRCA2 as the most commonly altered gene. Germline mutations in BRCA2 have been linked to poor prognosis when patients are managed under the protocols currently approved for prostate cancer. The impact of germline mutations in other DDR genes beyond BRCA2 remain unclear. Importantly, a quarter of prostate cancer patients identified as germline mutation carriers lack a family history of cancer. The clinical implications of somatic DDR defects are yet to be elucidated. Poly ADP-ribose polymerase (PARP) inhibitors and platinum-based chemotherapy have proven to be effective in the treatment of other tumor types linked to BRCA1 and BRCA2 alterations and several trials are currently evaluating their efficacy in prostate cancer. Here, we summarize the available evidence regarding the prevalence of somatic and germline DDR defects in prostate cancer; their association with clinical outcomes; the trials assessing the efficacy of new therapies that exploit DDR defects in prostate cancer and briefly discuss some uncertainties about the most appropriate management for these patients.
eng
BRCA2
DDR
DNA damage and repair
PARP inhibitors
prostate cancer
BRCA2 and Other DDR Genes in Prostate Cancer
journal article
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URL
https://repisalud.isciii.es/bitstreams/48101bca-0d0f-4d72-9b23-2aeded04ef3e/download
File
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application/pdf
BRCA2andOtherDDRGenes_2019.pdf
URL
https://repisalud.isciii.es/bitstreams/d0778c4e-aa19-475c-ae7c-cfc112354650/download
File
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BRCA2andOtherDDRGenes_2019.pdf.txt