2026-06-14T03:31:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78352024-11-29T22:53:52Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Cascon Soriano, Alberto
author
Remacha, Laura
author
Calsina, Bruna
author
Robledo Mercedes, Mercedes
funder
Instituto de Salud Carlos III
funder
European Regional Development Fund
2019-07-02T08:22:27Z
2019-07-02T08:22:27Z
2019-05-16
Cancers (Basel). 2019;11(5). pii: E683.
10.3390/cancers11050683
2072-6694
Cancers
31100940
http://hdl.handle.net/20.500.12105/7835
Abstract: Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumors that show the highest heritability of all human neoplasms and represent a paradoxical example of genetic heterogeneity. Amongst the elevated number of genes involved in the hereditary predisposition to the disease (at least nineteen) there are eleven tricarboxylic acid (TCA) cycle-related genes, some of which are also involved in the development of congenital recessive neurological disorders and other cancers such as cutaneous and uterine leiomyomas, gastrointestinal tumors and renal cancer. Somatic or germline mutation of genes encoding enzymes catalyzing pivotal steps of the TCA cycle not only disrupts cellular respiration, but also causes severe alterations in mitochondrial metabolite pools. These latter alterations lead to aberrant accumulation of "oncometabolites" that, in the end, may lead to deregulation of the metabolic adaptation of cells to hypoxia, inhibition of the DNA repair processes and overall pathological changes in gene expression. In this review, we will address the TCA cycle mutations leading to the development of PPGL, and we will discuss the relevance of these mutations for the transformation of neural crest-derived cells and potential therapeutic approaches based on the emerging knowledge of underlying molecular alterations.
eng
TCA cycle
germline mutation
paraganglioma
pheochromocytoma
Pheochromocytomas and Paragangliomas: Bypassing Cellular Respiration
journal article
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PheochromocytomasandParagangliomas Bypassing_2019.pdf
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PheochromocytomasandParagangliomas Bypassing_2019.pdf.txt