2026-04-29T12:23:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78272024-11-29T14:39:17Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Sánchez, Ricardo
author
Ayala, Rosa
author
Martinez-Lopez, Joaquin
funder
Fundación CRIS contra el Cáncer
2019-07-01T12:00:55Z
2019-07-01T12:00:55Z
2019-06-10
Int J Mol Sci. 2019;20(11). pii: E2832.
10.3390/ijms20112832
1422-0067
1422-0067
International journal of molecular sciences
31185671
http://hdl.handle.net/20.500.12105/7827
Ultra-deep next-generation sequencing has emerged in recent years as an important diagnostic tool for the detection and follow-up of tumor burden in most of the known hematopoietic malignancies. Meticulous and high-throughput methods for the lowest possible quantified disease are needed to address the deficiencies of more classical techniques. Precision-based approaches will allow us to correctly stratify each patient based on the minimal residual disease (MRD) after a treatment cycle. In this review, we consider the most prominent ways to approach next-generation sequencing methodologies to follow-up MRD in hematological neoplasms.
eng
clonal evolution
hematological neoplasms
high-throughput sequencing
minimal residual disease
next-generation sequencing
Minimal Residual Disease Monitoring with Next-Generation Sequencing Methodologies in Hematological Malignancies
journal article
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MinimalResidualDiseaseMonitoring_2019.PDF
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MinimalResidualDiseaseMonitoring_2019.PDF.txt