2026-06-14T05:08:07Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78262024-11-29T17:31:22Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Álvaro, Edurne author Cano, Juana M author García, Juan L author Brandáriz, Lorena author Olmedillas-López, Susana author Arriba, María author Rueda, Daniel author Rodríguez, Yolanda author Cañete, Ángel author Arribas, Julia author Inglada Perez, Lucia author Pérez, Jessica author Gómez, Carlos author García-Arranz, Mariano author García-Olmo, Damián author Goel, Ajay author Urioste, Miguel author González-Sarmiento, Rogelio author Perea, José author 2019-02-22 Our aim was to characterize and validate that the location and age of onset of the tumor are both important criteria to classify colorectal cancer (CRC). We analyzed clinical and molecular characteristics of early-onset CRC (EOCRC) and late-onset CRC (LOCRC), and we compared each tumor location between both ages-of-onset. In right-sided colon tumors, early-onset cases showed extensive Lynch syndrome (LS) features, with a relatively low frequency of chromosomal instability (CIN), but a high CpG island methylation phenotype. Nevertheless, late-onset cases showed predominantly sporadic features and microsatellite instability cases due to BRAF mutations. In left colon cancers, the most reliable clinical features were the tendency to develop polyps as well as multiple primary CRC associated with the late-onset subset. Apart from the higher degree of CIN in left-sided early-onset cancers, differential copy number alterations were also observed. Differences among rectal cancers showed that early-onset rectal cancers were diagnosed at later stages, had less association with polyps, and more than half of them were associated with a familial LS component. Stratifying CRC according to both location and age-of-onset criteria is meaningful, not only because it correlates the resulting categories with certain molecular bases, but with the confirmation across larger studies, new therapeutical algorithms could be defined according to this subclassification. Int J Mol Sci. 2019;20(4). pii: E968. 10.3390/ijms20040968 1422-0067 1422-0067 International journal of molecular sciences 30813366 http://hdl.handle.net/20.500.12105/7826 CpG island methylator phenotype Chromosomal instability Early-onset colorectal cancer Late-onset colorectal cancer Microsatellite instability Tumor location. Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location: Two Main Criteria for Subclassifying Colorectal Cancer