2026-07-21T14:27:00Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78182025-05-26T13:38:46Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_19614col_20.500.12105_16962
Repisalud
author
García-Pérez, Javier
author
Pollan-Santamaria, Marina
author
Perez-Gomez, Beatriz
author
Gonzalez-Sanchez, Mario
author
Cortes-Barragan, Rosana
author
Maqueda-Blasco, Jeronimo
author
González-Galarzo, María Carmen
author
Alba, Miguel Ángel
author
van der Haar, Rudolf
author
Casas, Silvia
author
Vicente, Cándida
author
Medina, Pilar
author
Ederra, María
author
Santamariña, Carmen
author
Moreno, María Pilar
author
Casanova, Francisco
author
Pedraz-Pingarrón, Carmen
author
Moreo, Pilar
author
Ascunce, Nieves
author
García, Montse
author
Salas-Trejo, Dolores
author
Sánchez-Contador, Carmen
author
Llobet, Rafael
author
Lope Carvajal, Virginia
funder
Asociación Española Contra el Cáncer
funder
Instituto de Salud Carlos III
2019-06-28T08:13:57Z
2019-06-28T08:13:57Z
2017
Environ Res. 2017 Nov;159:355-361
10.1016/j.envres.2017.08.028
1096-0953
0013-9351
Environmental research
28843166
http://hdl.handle.net/20.500.12105/7818
INTRODUCTION: High mammographic density is one of the main risk factors for breast cancer. Although several occupations have been associated with breast cancer, there are no previous occupational studies exploring the association with mammographic density. Our objective was to identify occupations associated with high mammographic density in Spanish female workers. METHODS: We conducted a population-based cross-sectional study of occupational determinants of high mammographic density in Spain, based on 1476 women, aged 45-68 years, recruited from seven screening centers within the Spanish Breast Cancer Screening Program network. Reproductive, family, personal, and occupational history data were collected. The latest occupation of each woman was collected and coded according to the 1994 National Classification of Occupations. Mammographic density was assessed from the cranio-caudal mammogram of the left breast using a semi-automated computer-assisted tool. Association between mammographic density and occupation was evaluated by using mixed linear regression models, using log-transformed percentage of mammographic density as dependent variable. Models were adjusted for age, body mass index, menopausal status, parity, smoking, alcohol intake, educational level, type of mammography, first-degree relative with breast cancer, and hormonal replacement therapy use. Screening center and professional reader were included as random effects terms. RESULTS: Mammographic density was higher, although non-statistically significant, among secondary school teachers (eβ = 1.41; 95%CI = 0.98-2.03) and nurses (eβ = 1.23; 95%CI = 0.96-1.59), whereas workers engaged in the care of people (eβ = 0.81; 95%CI = 0.66-1.00) and housewives (eβ = 0.87; 95%CI = 0.79-0.95) showed an inverse association with mammographic density. A positive trend for every 5 years working as secondary school teachers was also detected (p-value = 0.035). CONCLUSIONS: Nurses and secondary school teachers were the occupations with the highest mammographic density in our study, showing the latter a positive trend with duration of employment. Future studies are necessary to confirm if these results are due to chance or are the result of a true association whose causal hypothesis is, for the moment, unknown.
eng
Breast cancer
DDM-Occup
Mammographic density
Nurses
Occupation
School teachers
Occupation and mammographic density: A population-based study (DDM-Occup)
research article
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OccupationMammographicDensityPopulation_2017.pdf
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OccupationMammographicDensityPopulation_2017.pdf.txt
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