2026-06-14T05:06:26Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78172025-06-17T13:39:57Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974col_20.500.12105_19616
Repisalud
author
García-Pérez, Javier
author
Lopez-Abente, Gonzalo
author
Gomez-Barroso, Diana
author
Morales-Piga, Antonio
author
Romaguera, Elena Pardo
author
Tamayo, Ibon
author
Fernandez-Navarro, Pablo L
author
Ramis, Rebeca
funder
Instituto de Salud Carlos III
2019-06-28T07:47:50Z
2019-06-28T07:47:50Z
2015-07
Environ Res. 2015 Jul;140:542-53.
10.1016/j.envres.2015.05.014
1096-0953
0013-9351
Environmental research
26025512
http://hdl.handle.net/20.500.12105/7817
BACKGROUND: Few risk factors for the childhood leukemia are well established. While a small fraction of cases of childhood leukemia might be partially attributable to some diseases or ionizing radiation exposure, the role of industrial and urban pollution also needs to be assessed. OBJECTIVES: To ascertain the possible effect of residential proximity to both industrial and urban areas on childhood leukemia, taking into account industrial groups and toxic substances released. METHODS: We conducted a population-based case-control study of childhood leukemia in Spain, covering 638 incident cases gathered from the Spanish Registry of Childhood Tumors and for those Autonomous Regions with 100% coverage (period 1990-2011), and 13,188 controls, individually matched by year of birth, sex, and autonomous region of residence. Distances were computed from the respective subject's residences to the 1068 industries and the 157 urban areas with ≥10,000 inhabitants, located in the study area. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance to industrial and urban pollution sources were calculated, with adjustment for matching variables. RESULTS: Excess risk of childhood leukemia was observed for children living near (≤2.5 km) industries (OR=1.31; 95%CI=1.03-1.67) - particularly glass and mineral fibers (OR=2.42; 95%CI=1.49-3.92), surface treatment using organic solvents (OR=1.87; 95%CI=1.24-2.83), galvanization (OR=1.86; 95%CI=1.07-3.21), production and processing of metals (OR=1.69; 95%CI=1.22-2.34), and surface treatment of metals (OR=1.62; 95%CI=1.22-2.15) - , and urban areas (OR=1.36; 95%CI=1.02-1.80). CONCLUSIONS: Our study furnishes some evidence that living in the proximity of industrial and urban sites may be a risk factor for childhood leukemia.
eng
Case–control study
Childhood leukemia
Industrial pollution
Residential proximity
Urban pollution
Childhood leukemia and residential proximity to industrial and urban sites
research article
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