2026-05-17T00:18:31Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78112024-11-29T17:44:30Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Arriba, María
author
Sánchez, Carmen
author
Vivas, Alfredo
author
Nutu, O A
author
Rueda, Daniel
author
Tapial, Sandra
author
Rodríguez, Yolanda
author
Brandáriz, Lorena
author
García, Juan L
author
García-Olmo, Damián
author
Goel, Ajay
author
González-Sarmiento, Rogelio
author
Urioste, Miguel
author
Perea, José
funder
National Institutes of Health (Estados Unidos)
funder
Ministerio de Sanidad y Consumo (España)
funder
Cancer Prevention and Research Institute of Texas (Estados Unidos)
funder
Sammons Cancer Center and Baylor Foundation (Estados Unidos)
funder
Baylor Scott & White Research Institute (Estados Unidos)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2019-06-27T09:47:56Z
2019-06-27T09:47:56Z
2019
PLoS One. 2019;14(5):e0216472.
10.1371/journal.pone.0216472
1932-6203
1932-6203
PloS one
31095598
http://hdl.handle.net/20.500.12105/7811
Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC.
eng
CHROMOSOMAL INSTABILITY
HMLH1 PROMOTER
MICROSATELLITE
PROGNOSIS
METHYLATION
EXPRESSION
Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer
journal article
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
URL
https://repisalud.isciii.es/bitstreams/94f83a0e-16bc-4d91-90e8-d1f967bbafd9/download
File
MD5
bd1ac5305cb7b285502aa6defc677d8d
512701
application/pdf
Intermediate-onsetcolorectalcancer_2017.pdf
URL
https://repisalud.isciii.es/bitstreams/877afb1a-fdc5-4b17-9485-a8a4711510d9/download
File
MD5
f32c9a9300b0e62efa4a9b88d7082fd8
68096
application/msword
Intermediate-onsetcolorectalcancer_table12017.doc
URL
https://repisalud.isciii.es/bitstreams/5c107ee9-3a39-459f-b432-013261c2461d/download
File
MD5
d6b062cad5e3d110e510f4859e673b75
14138
application/vnd.openxmlformats-officedocument.wordprocessingml.document
Intermediate-onsetcolorectalcancer_table2.2017.doc.docx
URL
https://repisalud.isciii.es/bitstreams/3d00a923-97ca-4e61-aae8-f293a1adeef9/download
File
MD5
edc3ba15aab20a03d914b97c4ccb06b9
41393
text/plain
Intermediate-onsetcolorectalcancer_2017.pdf.txt
URL
https://repisalud.isciii.es/bitstreams/481dc101-edae-4096-bbe9-297924bb28a0/download
File
MD5
cee88c083c14365322559c0d347d4ec7
701
text/plain
Intermediate-onsetcolorectalcancer_table12017.doc.txt
URL
https://repisalud.isciii.es/bitstreams/7a8a7b14-f809-45c6-8a73-f4968d9cbe22/download
File
MD5
e3498a8b77029a78869f3c153c2b8e9c
1257
text/plain
Intermediate-onsetcolorectalcancer_table2.2017.doc.docx.txt