2026-08-05T15:43:13Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/78112024-11-29T17:44:30Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Arriba, María author Sánchez, Carmen author Vivas, Alfredo author Nutu, O A author Rueda, Daniel author Tapial, Sandra author Rodríguez, Yolanda author Brandáriz, Lorena author García, Juan L author García-Olmo, Damián author Goel, Ajay author González-Sarmiento, Rogelio author Urioste, Miguel author Perea, José author 2019 Comparative studies of colorectal cancer (CRC) according to the age of onset have found differences between early-onset CRC (EOCRC) and late-onset CRC (LOCRC). Using this as a starting point, we wished to determine whether intermediate-onset CRC (IOCRC) might also be considered as an independent group within CRC. We performed a retrospective comparative study of the clinicopathological and familial features, as well as of the symptoms and their duration, of a total of 272 subjects diagnosed with CRC classified into three groups according to the age-of-onset (98 EOCRC, 83 IOCRC and 91 LOCRC). The results show that from a clinicopathological point of view, IOCRC shared certain features with EOCRC (gender, prognosis), and with LOCRC (multiple primary CRCs), whereas it also had characteristics that were specific for IOCRC (mean number of associated polyps). A gradual progression was observed from EOCRC to LOCRC from a greater family aggregation to sporadic cases, in parallel with a change of Lynch Syndrome cases to the sporadic microsatellite instability pathway, with the IOCRC being a boundary group that is more related to EOCRC. With respect to symptoms, duration and correlation with stages, IOCRC appeared more similar to EOCRC. Clinically, IOCRC behaves as a transitional group between EOCRC and LOCRC, with features in common with both groups, but also with IOCRC-specific features. Excluding cases with familial cancer history, the awareness for EOCRC diagnosis should be extended to IOCRC. PLoS One. 2019;14(5):e0216472. 10.1371/journal.pone.0216472 1932-6203 1932-6203 PloS one 31095598 http://hdl.handle.net/20.500.12105/7811 CHROMOSOMAL INSTABILITY HMLH1 PROMOTER MICROSATELLITE PROGNOSIS METHYLATION EXPRESSION Intermediate-onset colorectal cancer: A clinical and familial boundary between both early and late-onset colorectal cancer