2026-08-05T09:54:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78022025-05-05T07:39:56Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16962col_20.500.12105_16968col_20.500.12105_16983
Repisalud
author
García-Pérez, Javier
author
Lope Carvajal, Virginia
author
Perez-Gomez, Beatriz
author
Molina, Antonio José
author
Tardón, Adonina
author
Díaz Santos, María Angustias
author
Ardanaz, Eva
author
O'Callaghan-Gordo, Cristina
author
Altzibar, Jone M
author
Gómez-Acebo, Inés
author
Moreno, Victor
author
Peiró, Rosana
author
Marcos-Gragera, Rafael
author
Kogevinas, Manolis
author
Aragones, Nuria
author
Lopez-Abente, Gonzalo
author
Pollan-Santamaria, Marina
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Economía y Competitividad (España)
funder
Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España)
funder
Fundación Marqués de Valdecilla
funder
Regional Government of Andalusia (España)
funder
Junta de Castilla y León (España)
funder
Generalitat Valenciana (España)
funder
Basque Government (España)
funder
Fundación La Caixa
funder
Unión Europea. Comisión Europea
funder
Asociación Española Contra el Cáncer
funder
Government of Catalonia (España)
funder
University of Oviedo (España)
funder
Fundación Caja de Ahorros de Asturias
2019-06-26T09:03:20Z
2019-06-26T09:03:20Z
2018-06
Environ Pollut. 2018 Jun;237:559-568.
10.1016/j.envpol.2018.02.065
1873-6424
0269-7491
Environmental pollution (Barking, Essex : 1987)
29524878
http://hdl.handle.net/20.500.12105/7802
Breast cancer is the most frequent tumor in women worldwide, although well-established risk factors account for 53%-55% of cases. Therefore, other risk factors, including environmental exposures, may explain the remaining variation. Our objective was to assess the relationship between risk of breast cancer and residential proximity to industries, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Using the current residence of cases and controls, this study was restricted to small administrative divisions, including both breast cancer cases (452) and controls (1511) in the 10 geographical areas recruiting breast cancer cases. Distances were calculated from the respective woman's residences to the 116 industries located in the study area. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (between 1 km and 3 km) to industrial plants, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of breast cancer was found near industries overall (1.30; 1.00-1.69 at 3 km), particularly organic chemical industry (2.12; 1.20-3.76 at 2.5 km), food/beverage sector (1.87; 1.26-2.78 at 3 km), ceramic (4.71; 1.62-13.66 at 1.5 km), surface treatment with organic solvents (2.00; 1.23-3.24 at 3 km), and surface treatment of plastic and metals (1.51; 1.06-2.14 at 3 km). By pollutants, the excess risk (OR; 95%CI) was detected near industries releasing pesticides (2.09; 1.14-3.82 at 2 km), and dichloromethane (2.09; 1.28-3.40 at 3 km). Our results suggest a possible increased risk of breast cancer in women living near specific industrial plants and support the need for more detailed exposure assessment of certain agents released by these plants.
eng
Breast cancer
Case-control study
Endocrine disrupting chemicals
Industrial pollution
Pesticides
Residential proximity
Risk of breast cancer and residential proximity to industrial installations: New findings from a multicase-control study (MCC-Spain)
research article
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RiskBreastCancerResidential_2018.pdf
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Material.suplementario__RiskBreastCancerResidential.pdf.txt
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