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00925njm 22002777a 4500 dc García-Pérez, Javier author Lope Carvajal, Virginia author Perez-Gomez, Beatriz author Molina, Antonio José author Tardón, Adonina author Díaz Santos, María Angustias author Ardanaz, Eva author O'Callaghan-Gordo, Cristina author Altzibar, Jone M author Gómez-Acebo, Inés author Moreno, Victor author Peiró, Rosana author Marcos-Gragera, Rafael author Kogevinas, Manolis author Aragones, Nuria author Lopez-Abente, Gonzalo author Pollan-Santamaria, Marina author 2018-06 Breast cancer is the most frequent tumor in women worldwide, although well-established risk factors account for 53%-55% of cases. Therefore, other risk factors, including environmental exposures, may explain the remaining variation. Our objective was to assess the relationship between risk of breast cancer and residential proximity to industries, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Using the current residence of cases and controls, this study was restricted to small administrative divisions, including both breast cancer cases (452) and controls (1511) in the 10 geographical areas recruiting breast cancer cases. Distances were calculated from the respective woman's residences to the 116 industries located in the study area. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (between 1 km and 3 km) to industrial plants, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of breast cancer was found near industries overall (1.30; 1.00-1.69 at 3 km), particularly organic chemical industry (2.12; 1.20-3.76 at 2.5 km), food/beverage sector (1.87; 1.26-2.78 at 3 km), ceramic (4.71; 1.62-13.66 at 1.5 km), surface treatment with organic solvents (2.00; 1.23-3.24 at 3 km), and surface treatment of plastic and metals (1.51; 1.06-2.14 at 3 km). By pollutants, the excess risk (OR; 95%CI) was detected near industries releasing pesticides (2.09; 1.14-3.82 at 2 km), and dichloromethane (2.09; 1.28-3.40 at 3 km). Our results suggest a possible increased risk of breast cancer in women living near specific industrial plants and support the need for more detailed exposure assessment of certain agents released by these plants. Environ Pollut. 2018 Jun;237:559-568. 10.1016/j.envpol.2018.02.065 1873-6424 0269-7491 Environmental pollution (Barking, Essex : 1987) 29524878 http://hdl.handle.net/20.500.12105/7802 Breast cancer Case-control study Endocrine disrupting chemicals Industrial pollution Pesticides Residential proximity Risk of breast cancer and residential proximity to industrial installations: New findings from a multicase-control study (MCC-Spain)