2026-04-29T16:56:13Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/78002024-10-24T11:13:11Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Tamayo-Uria, Ibon
author
Boldo, Elena
author
García-Pérez, Javier
author
Gomez-Barroso, Diana
author
Romaguera, Elena Pardo
author
Cirach, Marta
author
Ramis, Rebeca
funder
Instituto de Salud Carlos III
funder
Asociación Española Contra el Cáncer
2019-06-26T08:21:28Z
2019-06-26T08:21:28Z
2018
Environ Int. 2018 Dec;121(Pt 1):332-339.
10.1016/j.envint.2018.08.056
1873-6750
0160-4120
Environment international
30241021
http://hdl.handle.net/20.500.12105/7800
BACKGROUND: Current evidence suggests that childhood leukaemia can be associated with residential traffic exposure; nevertheless, more results are needed to support this conclusion. OBJECTIVES: To ascertain the possible effects of residential proximity to road traffic on childhood leukaemia, taking into account traffic density, road proximity and the type of leukaemia (acute lymphoid leukaemia or acute myeloid leukaemia). METHODS: We conducted a population-based case-control study of childhood leukaemia in Spain, covering the period 1990-2011. It included 1061 incidence cases gathered from the Spanish National Childhood Cancer Registry and those Autonomous Regions with 100% coverage, and 6447 controls, individually matched by year of birth, sex and autonomous region of residence. Distances were computed from the respective participant's residential locations to the different types of roads and four different buffers. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (95%CIs), were calculated for four different categories of distance to roads. RESULTS: Cases of childhood leukaemia had more than three-fold increased odds of living at <50 m of the busiest motorways compared to controls (OR = 2.90; 95%CI = 1.30-6.49). The estimates for acute lymphoid leukaemia (ALL) were slightly higher (OR = 2.95; 95%CI = 1.22-7.14), while estimates for cases with the same address at birth and at diagnosis were lower (OR = 2.40; 95%CI = 0.70-8.30). CONCLUSIONS: Our study agrees with the literature and furnishes some evidence that living near a busy motorway could be a risk factor for childhood leukaemia.
eng
Case-control study
Childhood leukaemia
Residential proximity
Traffic density
Childhood leukaemia risk and residential proximity to busy roads
journal article
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ChildhoodLeukaemiaRiskAnd_2018.pdf
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ChildhoodLeukaemiaRiskAnd_2018.pdf.txt