2026-06-14T03:28:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77782025-06-06T09:36:37Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Gonzalez Portal, Maria Eugenia
author
Carrasco, Luis
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Dirección General de Investigación Científica y Técnica (España)
2019-06-17T09:15:09Z
2019-06-17T09:15:09Z
2003-09-18
FEBS Lett. 2003;552(1):28-34.
10.1016/S0014-5793(03)00780-4
1873-3468
0014-5793
FEBS letters
12972148
http://hdl.handle.net/20.500.12105/7778
Viroporins are a group of proteins that participate in several viral functions, including the promotion of release of viral particles from cells. These proteins also affect cellular functions, including the cell vesicle system, glycoprotein trafficking and membrane permeability. Viroporins are not essential for the replication of viruses, but their presence enhances virus growth. Comprising some 60-120 amino acids, viroporins have a hydrophobic transmembrane domain that interacts with and expands the lipid bilayer. Some viroporins also contain other motifs, such as basic amino acid residues or a domain rich in aromatic amino acids that confers on the protein the ability to interact with the interfacial lipid bilayer. Viroporin oligomerization gives rise to hydrophilic pores at the membranes of virus-infected cells. As the list of known viroporins steadily grows, recent research efforts focus on deciphering the actions of the viroporins poliovirus 2B, alphavirus 6K, HIV-1 Vpu and influenza virus M2. All these proteins can enhance the passage of ions and small molecules through membranes depending on their concentration gradient. Future work will lengthen the list of viroporins and will provide a deeper understanding of their mechanisms of action.
eng
Viroporins
research article
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URL
https://repisalud.isciii.es/bitstreams/4779aad5-40f3-4608-8899-7e5183abb7b1/download
File
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application/pdf
VIROPORINS_2003.pdf
URL
https://repisalud.isciii.es/bitstreams/d89e9a33-22e3-4384-aca7-0c32bd0bd07b/download
File
MD5
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text/plain
VIROPORINS_2003.pdf.txt