2026-06-16T13:58:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77762024-09-27T09:52:27Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Martin, Pilar
author
Moscat, Jorge
funder
Ministerio de Economía y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
National Institutes of Health (Estados Unidos)
2019-06-13T09:10:09Z
2019-06-13T09:10:09Z
2012
Front Immunol. 2012; 3:241
10.3389/fimmu.2012.00241
1664-3224
1664-3224
Frontiers in immunology
22888333
http://hdl.handle.net/20.500.12105/7776
The members of the atypical Protein Kinase Cs (aPKC) kinase subfamily, PKCζ and PKCλ/ɩ, as well as their adapters, p62 and Par-6, form part of the PB1-domain-containing group of signaling regulators. Both adapters serve to locate through heterotypic interactions the aPKCs into the NF-κB and cell polarity pathways, respectively. Both signaling cascades have been critically implicated in T cell function in vitro and in vivo. The analysis of gene-knockout (KO) mice deficient in the different PB1 molecules is providing more definitive information on the actual role that the aPKCs and other PB1-containing molecules play in B cell biology and T cell polarity, survival, and differentiation toward the different effector lineages in vivo and at the cellular ex vivo level. Here we discuss recent data generated from the analysis of KO mice linking the control of cell polarity by PKCλ/ɩ and PKCζ, their adapter p62, and the Par-4 inhibitor, in the control of B and T cell signaling and differentiation. Altogether, these genetic and biochemical evidences reveal the existence of a PB1-orchestrated signaling network that acts to control Th2 differentiation in vitro and in vivo, and the gene transcriptional programs that are essential during the B cell maturation and function and Th2 differentiation.
eng
B cells
T cells
Th1
Th2
Adaptive immune responses
Asthma
Atypical PKCs
Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators
journal article
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Th1-Th2DifferentiationBCell_2012.pdf
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Th1-Th2DifferentiationBCell_2012.pdf.txt