2026-04-29T16:55:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/77702024-09-27T08:06:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cogliati, Sara
author
Frezza, Christian
author
Soriano, Maria Eugenia
author
Varanita, Tatiana
author
Quintana-Cabrera, Ruben
author
Corrado, Mauro
author
Cipolat, Sara
author
Costa, Veronica
author
Casarin, Alberto
author
Gomes, Ligia C
author
Perales-Clemente, Ester
author
Salviati, Leonardo
author
Fernandez-Silva, Patricio
author
Enriquez, Jose Antonio
author
Scorrano, Luca
funder
Telethon Foundation (Italia)
funder
Swiss National Foundation
funder
Ministerio de Economía y Competitividad (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Comunidad de Madrid (España)
2019-06-13T07:11:07Z
2019-06-13T07:11:07Z
2013-09
Cell. 2013; 155(1):160-71
10.1016/j.cell.2013.08.032
1097-4172
0092-8674
Cell
24055366
http://hdl.handle.net/20.500.12105/7770
Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we investigate the relationship between respiratory function and mitochondrial ultrastructure and provide evidence that cristae shape determines the assembly and stability of RCS and hence mitochondrial respiratory efficiency. Genetic and apoptotic manipulations of cristae structure affect assembly and activity of RCS in vitro and in vivo, independently of changes to mitochondrial protein synthesis or apoptotic outer mitochondrial membrane permeabilization. We demonstrate that, accordingly, the efficiency of mitochondria-dependent cell growth depends on cristae shape. Thus, RCS assembly emerges as a link between membrane morphology and function.
eng
Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
journal article
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URL
https://repisalud.isciii.es/bitstreams/16869d7d-82b4-485b-b959-b8c20078f177/download
File
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application/pdf
MitochondrialCristaeShapeDetermines_2013.pdf
URL
https://repisalud.isciii.es/bitstreams/2a9849c4-5392-4eb3-9fa1-5e2316a76930/download
File
MD5
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text/plain
MitochondrialCristaeShapeDetermines_2013.pdf.txt