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oai:repisalud.isciii.es:20.500.12105/77702024-09-27T08:06:41Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Cogliati, Sara author Frezza, Christian author Soriano, Maria Eugenia author Varanita, Tatiana author Quintana-Cabrera, Ruben author Corrado, Mauro author Cipolat, Sara author Costa, Veronica author Casarin, Alberto author Gomes, Ligia C author Perales-Clemente, Ester author Salviati, Leonardo author Fernandez-Silva, Patricio author Enriquez, Jose Antonio author Scorrano, Luca author 2013-09 Respiratory chain complexes assemble into functional quaternary structures called supercomplexes (RCS) within the folds of the inner mitochondrial membrane, or cristae. Here, we investigate the relationship between respiratory function and mitochondrial ultrastructure and provide evidence that cristae shape determines the assembly and stability of RCS and hence mitochondrial respiratory efficiency. Genetic and apoptotic manipulations of cristae structure affect assembly and activity of RCS in vitro and in vivo, independently of changes to mitochondrial protein synthesis or apoptotic outer mitochondrial membrane permeabilization. We demonstrate that, accordingly, the efficiency of mitochondria-dependent cell growth depends on cristae shape. Thus, RCS assembly emerges as a link between membrane morphology and function. Cell. 2013; 155(1):160-71 10.1016/j.cell.2013.08.032 1097-4172 0092-8674 Cell 24055366 http://hdl.handle.net/20.500.12105/7770 Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency